Study Identifies Vitamin D's Benefits for Diabetic Heart Health

September 2009

Vitamin D may inhibit the build-up of cholesterol in blood vessels,

says a new study that calls for vitamin D supplements

to improve the heart health of diabetics.

According to new findings published in Circulation, diabetics—a population group at higher risk of heart disease—with low vitamin D levels displayed difficulties in processing cholesterol, putting them at an increased risk of heart attack and stroke.

"Vitamin D inhibits the uptake of cholesterol by cells called macrophages," explained lead researcher Carlos Bernal-Mizrachi, MD. "When people are deficient in vitamin D, the macrophage cells eat more cholesterol, and they can't get rid of it. The macrophages get clogged with cholesterol and become what scientists call foam cells, which are one of the earliest markers of atherosclerosis."

Macrophage activation is higher in people with disease such as diabetes, and when found in combination with low vitamin D levels, the macrophages become loaded with cholesterol and eventually stiffen blood vessels and block blood flow.

"Cholesterol is transported through the blood attached to lipoproteins such as LDL, the 'bad' cholesterol," he said. "As it is stimulated by oxygen radicals in the vessel wall, LDL becomes oxidated and macrophages eat it uncontrollably. LDL cholesterol then clogs the macrophages and that's how atherosclerosis begins."

And the problem may be solved by simply ensuring adequate vitamin D status via supplements, say researchers from Washington University in St. Louis.

"There is debate about whether any amount of sun exposure is safe,

so oral vitamin D supplements may work best," said Bernal-Mizrachi.

Vitamin D refers to two biologically inactive precursors—D3, also known as cholecalciferol and D2, also known as ergocalciferol. The former, produced in the skin on exposure to UVB radiation (290 to 320 nm), is said to be more bioactive. The latter is derived from plants and only enters the body via the diet from consumption of foods such as oily fish, egg yolk and liver.

Both D3 and D2 precursors are hydroxylated in the liver and kidneys to form 25-hydroxyvitamin D (25(OH)D), the non-active "storage" form, and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active form that is tightly controlled by the body.

Bernal-Mizrachi and his co-workers obtained macrophage cells from diabetics and non-diabetics, with and without vitamin D deficiency. When the cells were exposed to cholesterol and low vitamin D levels, they found that low vitamin D levels in the culture dish resulted in more macrophages becoming foam cells.

On the other hand, when the human macrophages were placed in a vitamin D-rich environment, the uptake of cholesterol was suppressed,

and they didn't become foam cells, Bernal-Mizrachi said.

The researchers noted that it may be possible to delay or reverse

the development of atherosclerosis in diabetics by helping them regain adequate vitamin D levels.

The next stage in the research is to look at vitamin D-deficient diabetics who also have high blood pressure. Bernal-Mizrachi said he wants to learn whether replacing vitamin D will lower blood pressure and improve blood flow.

yikes, solar flares? of course it is deadly, solar flares are like atomic bomb exploded from the surface of the sun. that is why vitamins is only on early in the morning.. and not in the mid day (noon)

yeah, it's nice to hear that you also know about the solar flares. so there's a possibility that we will be having a hard time getting vitamin D from the sun. :wacko:

yeah, it's nice to hear that you also know about the solar flares. so there's a possibility that we will be having a hard time getting vitamin D from the sun. :wacko:

 

why do you think so? all you need to do is to go under the sun early in the morning.. a little jogging would do some help...and make sure that the sun will see you.

but what if it's already too hot even if its early in the morning? :rolleyes: i just thought about that. anyway maybe we can just take vitamin D in form of capsules. :wacko:

the problem with capsule is that it may contain chemicals that gives out side effect to your body.. the best way to get vitamin D is acquiring it naturally, the best is the sun's heat early in the morning. DO you think it is already hot in 6 in the morning? when the sun is still level with the horizon.

6 am sunshine is still healthy, just don't extend up to noon because its no longer good for the body and higher risk for skin cancer.

Some textbooks (If I remember it correctly) says 6-8 am sunshine is best for the body.

yes my father go out during that time, 6-8am. to get his natural vitamin D everyday. that was his doctor's advice. :smile: for him to easily recover.

Shortly about vitamin D benefits:

If you want to be healthier, live longer, get stronger, and keep your brain performing optimally, having adequate levels of vitamin D is the answer. 

1. Vitamin D fights disease1

In addition to its primary benefits, research suggests that vitamin D may also play a role in:

• reducing your risk of multiple scllerosis, according to a 2006 study published in the Jouranl of the American Medial Association
• decreasing your chance of developing heart disease, according to 2008 findings published in Cirulation
• helping to reduce your likelihood of developing the flu, according to 2010 research published in the American Journal of Clinical Nutrition

2. Vitamin D reduces depression

Research has shown that vitamin D might play an important role in regulating mood and warding off depression. In one study, scientists found that people with depression who received vitamin D supplements noticed an improvement in their symptoms.

In another study of people with fibromyalgia, researchers found vitamin D deficiency was more common in those who were also experiencing anxiety and depression.

 

3. Vitamin D boosts weight loss

Consider adding vitamin D supplements to your diet if you’re trying to lose weight or prevent heart disease. You can find a great selection of vitamin D supplements on Amazon.com 

In one study, people taking a daily calcium and vitamin D supplement were able to lose more weight than subjects taking a placebo supplement. The scientists said the extra calcium and vitamin D had an appetite-suppressing effect.

In another study, overweight people who took a daily vitamin D supplement improved their heart disease risk markers.

Nice to know how different substances affect your body. And that's why I've been reading so many reviews before I chose a male enhancement supplement to treat my erectile dysfunction.

Thanks for sharing such a handy content with us. I think it is the most important thing to take care of our health as health is the most precious thing in the world. An unhelathy body is useless as a patient can never enjoy his /her life.

If vitamin D is suitable for people who are often trading forex?

Thank you for the helpful info here. Yes, vitamins are really helpful and you should take them all 😄 But do you think the brand matters? I often take some pills and supplements and I think they are great. But maybe you can recommend something else to me?

This issues occupy the second place in the rating of endocrine disease, following diabetes. The thyroid is a small gland located in the front of the neck; its shape resembles a butterfly. There are many glands in the body responsible for hormone function. But thyroid has a special role: it produces hormones that are essential for proper metabolism. They are called thyroxine and triiodothyronine. If the thyroid is out of order, other glands in the body also can’t work properly: adrenals, gonads, and pituitary. Consequently, it affects nervous and immune system.

A human body produces nutrient D as a reaction to sun introduction. An individual can likewise support their nutrient D admission through specific nourishments or enhancements. 

Nutrient D is fundamental for a few reasons, including keeping up sound bones and teeth. It might likewise secure against a scope of sicknesses and conditions, for example, type 1 diabetes. 

In spite of its name, nutrient D isn't a nutrient, yet a prohormone, or antecedent of a hormone. 

Nutrients will be supplements that the body can't make, thus an individual must expend them in the eating routine. In any case, the body can deliver nutrient D. 

In this article, we take a gander at the advantages of nutrient D, what befalls the body when individuals don't get enough, and how to support nutrient D admission 

some benefits of vitamin D---

1. Solid bones 

2. Diminished danger of influenza 

3. Solid newborn children 

4. Solid pregnancy

On 2/24/2011 at 6:15 AM, pjbabia said:

the problem with capsule is that it may contain chemicals that gives out side effect to your body.. the best way to get vitamin D is acquiring it naturally, the best is the sun's heat early in the morning. DO you think it is already hot in 6 in the morning? when the sun is still level with the horizon.

We don't know that for sure. There are multiple factors that contribute, I'm actually found out one of the source where I've recently ordered Vit D capsules. I take D3 supplement 5,000 iu every other day and where I live everyone takes Vit D. I wouldn’t say I have more energy (as it's been a few weeks), but I don’t feel as worn down as I did.

We don't know that for sure. There are multiple factors that contribute, I'm actually found out one of the source here where I've recently ordered Vit D capsules. I take D3 supplement 5,000 iu every other day and where I live everyone takes Vit D. I wouldn’t say I have more energy (as it's been a few weeks), but I don’t feel as worn down as I did.

The long-lasting history of Chrissy planning to get rid of unwanted pounds and doing that had become an inspiring tale for many. The very best case here is that the author of the series, Dan Fogelman, stands for support to Metz. There are no obstacles for Chrissy to lose her weight as she wants. In addition, she has the opportunity to earn funds, dedicated and believing fans, and nominations for Emmy https://whatroseknows.com/chrissy-metz-weight-loss/  .

I take Vitamin D daily. It is important today.

Yes, current situation in the world makes us take care of health. When the pandemic began, I started taking Vitamin D on a daily basis. According to the latest research and the USA Online Pharmacy, its level plays a great role in the progress of the disease.